There are times doctors get pretty confused and frustrated by the research that is produced, particularly when it is not within their own specialty. What chance therefore do patients have?
Here is a paper telling us that too much fructose is bad for you. Now this upsets me because I have always considered I eat a healthy diet that contains vast amounts of fruit, which of course is teeming with fructose. Do I now need to reconsider that what I am eating? Is my high fruit intake unhealthy?
Although they are addressing the fructose content of corn syrup as an additive added as a sweetener by the food industry, what are the implications for those of us who do not eat many packaged foods but eat a diet full of fruits and vegetables where fruits predominate over vegetables?
I have just read the abstract of this paper. I suppose I’m going to have to study the whole paper in more detail and any subsequent follow-up papers too.
COUNTRY : CANADA
Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The “obesity epidemic” appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in the amount of dietary fructose consumption from high intake of sucrose and high fructose corn syrup, a common sweetener used in the food industry. A high flux of fructose to the liver, the main organ capable of metabolizing this simple carbohydrate, perturbs glucose metabolism and glucose uptake pathways, and leads to a significantly enhanced rate of de novo lipogenesis and triglyceride (TG) synthesis, driven by the high flux of glycerol and acyl portions of TG molecules from fructose catabolism. These metabolic disturbances appear to underlie the induction of insulin resistance commonly observed with high fructose feeding in both humans and animal models. Fructose-induced insulin resistant states are commonly characterized by a profound metabolic dyslipidemia, which appears to result from hepatic and intestinal overproduction of atherogenic lipoprotein particles. Thus, emerging evidence from recent epidemiological and biochemical studies clearly suggests that the high dietary intake of fructose has rapidly become an important causative factor in the development of the metabolic syndrome. There is an urgent need for increased public awareness of the risks associated with high fructose consumption and greater efforts should be made to curb the supplementation of packaged foods with high fructose additives. The present review will discuss the trends in fructose consumption, the metabolic consequences of increased fructose intake, and the molecular mechanisms leading to fructose-induced lipogenesis, insulin resistance and metabolic dyslipidemia.”
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